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Dose Escalation Schedule Because GI tolerability limits rapid up-titration, the phase 2 obesity program used a structured titration: starting at 2 mg weekly for 4 weeks, advancing to 4 mg for 4 weeks, then stepping to the target maintenance dose (8 mg or 12 mg) [5]

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Safety Monitoring and When to Contact Your Doctor Patients on both semaglutide and Lexapro should report new or worsening anxiety, mood changes, unusual appetite loss lasting more than 2 weeks, or severe persistent nausea to their prescriber