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Both the GLP-1R/GIP coagonist and the tri-agonist similarly reduced blood glucose levels and improved glucose tolerance without induction of hypoglycaemia, and this demonstrates that chronic GCGR agonism does not overpower the anti-hyperglycemic effects of GLP-1R and GIPR activation

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Targeted injection of exendin-4 into the laterodorsal tegmental nucleus suppressed cocaine-seeking behavior in rats, without affecting body weight, food intake, or sucrose-seeking behavior

However, further studies are needed to assess whether GGT plays a mechanistic role in the pathophysiology of idiopathic pulmonary hypertension or the risk stratification of patients with this disease