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Given the striking decrease of 55% of cells entering the S-phase of the cell cycle upon treatment with 2 ng/mL and 10 ng/mL of BPC 157 and decreased ERK phosphorylation, it was suggested that BPC 157 acts as an antimitogenic agent by preventing ERK phosphorylation and the propagation of the mitogenic signal via the MAPK signaling cascade, triggered by VEGF [95]

In topical studies, side effects are minimal and usually limited to mild skin irritation in sensitive individuals

[DOI] [PubMed] [Google Scholar] 116.Quilliot D., Coupaye M., Ciangura C., Czernichow S., Sall A., Gaborit B., Alligier M., Nguyen-Thi P.L., Dargent J., Msika S

Microvasculature changes and cerebral amyloid angiopathy in Alzheimers disease and their potential impact on therapy