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Endothelial damage can be provoked by a number of mechanisms, such as a change in the surface tension of the plasma membrane or modification of the physicalchemical milieu of the endothelial cell through a change of intravascular pH or osmolality

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Designing and manufacturing auto disable syringes and protective devices The World Health Organization (WHO), aware of the unsafe injection practices in most health facilities, urges device manufacturers to design and manufacture auto disable syringes and needles