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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)

Therefore, potential selection bias cannot be excluded, and reproducibility is inherently limited compared to systematic analyses

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The removal of this region and the multivalent presentation on a ferritin nanoparticle significantly improved DCFHPs neutralizing potency in mice relative to the use of unedited spike, since it allows the immune system to not get distracted by creating an antibody response against a region that is ultimately nonneutralizing [134]