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This study also reported that Schwann cell-specific MCT1 is necessary for long-term maintenance of motor end-plate integrity, which was not investigated in our Schwann cell-specific MCT1 null mice, while MCT4 appears largely dispensable for the support of motor neurons ( FIGURE 1 Lactate transport through MCT1 in the PNS also has an essential role in axonal regeneration following injury, potentially through metabolic support from Schwann cells to axons (Morrison et al., 2015)

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doi:10.1172/JCI59755 [PMC Full Text] [PubMed] [Crosslink] Watkins PB, Kaplowitz N, Slattery JT, et al

Biol Rev Camb Philos Soc 91:452468