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However, lower inflammatory markers do not prove that it will relieve a specific joint condition or treat inflammatory arthritis

Final Thoughts: Retatrutide Side Effects Retatrutide side effects are usually mild, temporary, and most noticeable during the first few weeks or after dose increases

Side effects tend to mirror those of GLP-1 agonists: Nausea Diarrhea Decreased appetite Possible gallbladder effects (as with all rapid weight loss) Minimal risk of hypoglycemia when used without insulin Importantly, GIP on its own does not cause hypoglycemia , making it a relatively safe therapeutic target

Findings presented at the SCAI 2026 Scientific Sessions & CAIC-ACCI Summit in Montreal in April indicate that GLP-1 medications containing tirzepatide (Mounjaro and Zepbound) may help lower the risk of heart problems in people with obesity undergoing certain heart procedures