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Senescent cells secrete factors known as the senescence-associated secretory phenotype (SASP), which can contribute to chronic inflammation and create a microenvironment favorable for cancer progression

However, this gives a signal of a favorable effect of GLP-1 receptor agonist therapy in the COPD population, as was also previously shown in a similar study in the UK, where a 30% reduction per 100 person years of severe exacerbations was recorded in GLP-1 receptor agonist users compared to sulfonylurea users, as well as a 37% reduction per 100 person years of moderate exacerbations

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