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Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)

Avg Glu (eAG) Globulin, Total Glucose HDL Cholesterol Hematocrit Hemoglobin Immature Grans (Abs) Immature Granulocytes Insulin LDL Chol Calc (NIH) LDL Cholesterol Lymphocytes Lymphs (Absolute) MCH MCHC MCV Monocytes Monocytes (Absolute) Neutrophils Non HDL Cholesterol Platelet Count Potassium Protein, Total RBC RDW Sodium Triglycerides TSH Uric Acid VLDL Cholesterol Cal WBC Notice: Biomarkers tested may vary slightly between labs

Unlike monoclonal antibodies that physically block PD-1/PD-L1 interactions, these agents reprogram the immunosuppressive milieu by simultaneously affecting tumor cells, tumor-associated macrophages, regulatory T cells, and inflammatory cytokine networks