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Guideline for good clinical practice E6(R1), Step 4

If youre waking up feeling tired even after 7 or 8 hours of sleep, it may be because your sleep cycles are disrupted, and you may not be achieving the balance of REM and deep sleep needed for recovery

[8] [9] The net effect of combining these agents on glycaemic control is unpredictable and could result in dysglycaemia particularly hyperglycaemia or worsening insulin resistance especially in individuals with pre-existing impaired glucose tolerance or type 2 diabetes