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We conducted a comprehensive literature search across databases, including PubMed and Web of Science, compiling data from clinical trials, case reports, and basic research studies published up to 2025, with a focus on the efficacy, safety, and mechanism of action of drugs such as liraglutide, semaglutide, and tirzepatide in patients with MC4R deficiency

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Pathogens and the host immune response collectively dysregulate intracellular iron metabolism and ROS levels, ultimately leading to membrane damage via lipid peroxidation ( In this review, we present a comprehensive overview of ferroptosis in pathogen-related infections, discussing its implications for disease progression and treatment

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