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Conversely, the conditional knockout of Gpx4 in myeloid cells, blood progenitor cells, and sperm cells can increase pyroptosis, necroptosis, and apoptosis in response to specific stresses [120, 124, 125]
Unfavorable environmental conditions result in the formation of reactive oxygen species (ROS) in different subcellular compartments, which may intracellularly activate anti-oxidants (e.g., key player GSH) and defense responses leading to plant acclimation
Eid AH, Abdelkader NF, Abd El-Raouf OM et al (2016) Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation
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