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Melanosis typically is most intense in the cecum and diminishes in intensity down the length of the colon

However, Galloway sees a broader benefit from GLP-1 meds in treating depression, as obesity or overweight are the leading predictors of childhood and adult depression

Both peripheral gut effects and central brainstem modulation likely lower the hiccup reflex threshold, with a pharmacovigilance review finding 25 of 500 adverse reports involved hiccups (5%), and some trials noting hiccups in about 2% of participants