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Opioids are a class of drugs that include synthetic opioids like fentanyl and legal prescription pain relievers like oxycodone (OxyContin), hydrocodone (Vicodin), codeine, and morphine.[3] These drugs are prescribed for pain management with moderate to severe pain, though they have the side effect of creating a high thats often sought for recreational use

Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation

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mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists