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150 YamamotoK.AbeS.HondaA.HashimotoJ.AizawaY.IshibashiS.et al (2020)

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Notably, although both CCKRs adopt the canonical seven-transmembrane architecture, they differ from other reported class-A GPCRs with a shortened TM4 helix, which is attributed to the unwinding of the helix at the extracellular half caused by the presence of P 4.59 and the additional P 4.61 (the superscripts refer to the BallesterosWeinstein number) 44