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Acknowledgements We would like to thank Instituto do Osso e da Cartilagem for the support and Jos Fbio Lana for his remarkable academic contributions towards the production of this manuscript

Nevertheless, in contrast to the vast knowledge collected about the detoxification function of GSTs, the understanding of their role in endogenous plant processes and about their metabolic substrates had been still far from complete (Marrs, 1996

An overview of psychiatric issues in liver disease for the consultation-liaison psychiatrist