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Glu is then converted to -ketoglutarate (-KG) via glutamate dehydrogenase (GLUD1), which enters the tricarboxylic acid (TCA) cycle (Yao et al., 2021), -KG accumulation promotes oxidative stress by enhancing ROS production and lipid peroxidation, thereby inducing ferroptosis (Gao et al., 2015)

The Perimenopause Programme isnt designed simply to trouble-shoot individual symptoms, instead it takes a full 360 view of your health, considering the body as a dynamic set of interconnected systems that all have the potential to influence each other

Defining a unified rationale for DHA-induced regulation of Gpx4 gene expression Our initial observations in HT22 indicated that the upregulation of Gpx4 expression occurred with a significant delay form the initial exposure to DHA