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Notably, psychostimulants are known to induce oxidative stress, 55, 56, 57 whereas GLP-1R signaling, which reduces AA levels, is known to reduce it

Consistent with this notion, liver disease progression is associated not only with an increased risk of liver-related adverse outcomes from hepatic decompensation and hepatocellular carcinoma (HCC), but also increased all-cause, cardiovascular and extrahepatic cancer-related mortality, which are the leading causes of death in patients with MAFLD/MASH [2]