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A confirmatory secondary endpoint at Week 72 showed 33% of patients treated with Wegovy 2.4 mg achieved both resolution of steatohepatitis and improvement in liver fibrosis compared to 16% on placebo with a statistically significant difference in response rate vs placebo of 17 (95% CI, 10;23)

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Higher doses of Rybelsus have also been tested in people with type 2 diabetes in a study called the Pioneer Plus trial

Similar neuroprotective effects have been observed in mouse models of rotenone-induced PD as well, through the inhibition of -synuclein phosphorylation and aggregation, protection of mitochondrial function, inhibition of neuroinflammation, modulation of autophagy, attenuation of oxidative stress and restoration of ER balance (Wang D