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Additionally, researchers use preclinical models to examine how the metabolic effects of dual gastric inhibitory polypeptide (GIP)/GLP-1R agonists such as tirzepatide mediate anti-inflammatory and anti-fibrotic benefits, such as in metabolic dysfunction-associated steatotic liver disease

3.3 Immune metabolic reprogramming In an inflammatory state, immune cells undergo metabolic reprogramming, characterized primarily by enhanced glycolysis and diminished OXPHOS, to meet the heightened energy demands of the inflammatory response (141)

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