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We generated the Sox9-CreER mice by integrating IRES-CreERT2-SV40pA cassettes into the 3' UTR of the endogenous mouse Sox9 gene, before the aacatggaggacgattggagaatc sequence via Cas9/RNA mediated gene targeting in zygotes

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Preclinical studies have shown that antibiotics, probiotics, and fecal microbiota transplantation can alter the gut microbiota composition and reduce liver injury in APAP overdose by modulating inflammatory responses and enhancing hepatocyte regeneration