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High Triglycerides: Triglyceride levels equal to or greater than 150 mg/dL

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This distinction is clinically important: oral estrogens trigger a hepatic response that elevates clotting factors, C-reactive protein, sex hormone-binding globulin, and triglycerides, while transdermal formulations do not produce these effects at standard doses [9]

A range of studies have indicated the presence of specialized obesity-associated gut microbiota which may favor production of microbial fermentation products and metabolites increasing efficiency of energy harvest from ingested nutrients as well as modulating gut motility, permeability and immune function 9,10,11,12,13