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The ACC document, which was endorsed by the American Diabetes Association (ADA), outlined a variety of considerations for use of these agents in patients with ASCVD, including considerations that may warrant selection of either a GLP-1 RA or an SGLT-2 inhibitor for cardiovascular risk reduction ( Table 1 )

The agency also indicated it would soon remove the seven flagged compounds from the Category 2 restricted list in the interim a provisional measure that patients should not interpret as formal approval

In conclusion, reduction in obese patients with type 2 diabetes, preliminary data suggest that the combination of cagrilintide and semaglutide may exert a synergistic effect on weight loss but less than additive effect of HbA1c levels