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Another trial published in The Lancet in 2017 demonstrated that exenatide (Byetta) improved motor function in patients with Parkinson's disease, with some exploratory cognitive measures showing potential benefit, though the study was limited by small sample size and short duration

Restricting calories can lead to fatigue, making it more challenging to stay active and committed to exercise

In contrast, CR-fed females not only had reduced plaques, but had reduced glial activation relative to both CR and DL-fed mice, with substantially lower pro-inflammatory gene expression, suggesting that while caloric reduction alone may attenuate plaque pathology, the reduction in plaque deposition observed in the DL-fed mice may not be mediated by glial cells

Research peptides including retatrutide are legal to purchase for legitimate laboratory and research purposes in the United States