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When coupled to -arrestins, GPCRs are desensitized by abrogated coupling to G proteins and trafficked away from the cell surface, destined for either re-sensitization following their recycling back to the plasma membrane, or for final signal termination resulting from their degradation in lysosomes (McCorvy et al., 2017)

The binding site is located near the extracellular face of the TMD, wedged between helices in a region that is not contacted by peptide agonists

Semaglutide GLP-1 is a desirable option for our patients with Type 2 diabetes since it more successfully improves glycemic control