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Rogers JE, Li F, Coatney DD, et al

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Berberine significantly inhibits the increase of Verrucomicrobia at the phylum level, inhibits Akkermansia at the genus level, and elevates the levels of SCFA-producing bacteria ( Lachnospiraceae ) ( Lactobacillus and Dubosiella , and an increase in abundance of undesirable bacteria Bacteroides , Escherichia, Shigella , and Akkermansia

41 Orforglipron, an oral small-molecule, nonpeptide GLP-1 receptor agonist, has also demonstrated weight loss comparable to injectable GLP-1 receptor agonists