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Additionally, iron overload in ferroptosis is further modulated by key metal ion transporters, including solute carrier family 39 member 14 (Slc39a14) and solute carrier family 39 member 8 (Slc39a8) ( Together, the processes of ferritinophagy, mediated by NCOA4, and enhanced iron import via Slc39a14 and Slc39a8 synergistically increase intracellular iron levels, solidifying their roles as critical factors in regulating ferroptosis

Effect of hydrogen peroxide on cell death in BSO-treated cells

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