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Safety across the full program was consistently favorable: adverse events, primarily mild headache and gastrointestinal symptoms, occurred at rates comparable to placebo, with no treatment-related discontinuations, no IGF-1 elevation, and no impact on glucose metabolism

For injectable semaglutide, doses start at 0.25 mg per week and may increase to a maximum of 2 mg (Ozempic) or 2.4 mg (Wegovy) weekly. For oral semaglutide (Rybelsus), doses start at 3 mg daily and increase to a maximum of 14 mg

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Within the first few weeks, patients often begin to notice subtle yet meaningful improvements such as reduced appetite, smaller portion sizes, or steadier blood sugar levels