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MOTS-c Research & Scientific Overview Jump to: Structure | Mechanism | Studies | Pharmacokinetics | Protocols | Limitations | Lead Researcher | References MOTS-c Molecular Structure & Chemical Properties MOTS-c peptide represents a paradigm-shifting discovery in mitochondrial biology, being the first mitochondrial-encoded peptide shown to directly regulate nuclear gene expression in response to metabolic stress

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The mechanism behind potential synergy involves multiple appetite-regulation pathways: GLP-1 signaling in the hypothalamus and gut, combined with naltrexone's effects on pro-opioidergic appetite signals

10.1016/0028-3908(94)90039-6 Neuropharmacology 149 MuscoliC.CuzzocreaS.NdengeleM