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Liver Disease (MASLD/NAFLD) Metabolic dysfunction-associated steatotic liver disease (MASLD) formerly known as nonalcoholic fatty liver disease (NAFLD) involves a buildup of fat in the liver that often occurs alongside metabolic disorders such as obesity and insulin resistance

Surprisingly, the SURMOUNT-5 trial found that fewer people discontinued tirzepatide due to side effects (2.7%) compared to semaglutide (5.6%)

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The underlying mechanism is as follows: in the presence of the terminal electron acceptor -oxygen- the electron transport chain maintains oxidation of NADH to NAD + by complex I, and this NAD + is supporting dehydrogenases, including the pyruvate dehydrogenase complex