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Supplementation is only necessary for pharmacological (therapeutic) dosing above physiological levels [1]

Methodological advantages over vial-and-syringe workflows A mechanical click-stop dial removes the volumetric variance introduced by manual draws from a reconstituted vial, delivering tighter dose reproducibility across subjects because each increment is pre-calibrated and sealed

1) from 3,4- cis -leucoanthocyanidins ( 2 ) to anthocyanidins ( 3 ) is thought to be catalysed by the Fe/-ketoglutarate-dependent dioxygenase leucoanthocyanidin dioxygenase (LDOX), also called anthocyanidin synthase (ANS) 8,9