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Afamelanotide or SCENESSE is undergoing trial for its potential photoprotective effect for patients with various dermatological conditions including vitiligo, erythropoetic protoporphyria, immunosuppressed transplant patients at risk of developing non-melanoma skin cancer, solar urticaria and polymorphic light eruption [10]

Figures and data visualizations were generated using EnhancedVolcano (v1.14.0) (65) for volcano plots, ComplexHeatmap (v2.9.4) (67) and circlize (v0.4.12) for heatmaps, ggplot2 (v3.5.0) for plotting, ggh4x (v0.2.5) for advanced facet layouts, and scales (v1.3.0) for gradient and size transformations

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General peptide safety KPV, derived from a naturally occurring human peptide (alpha-MSH), has shown minimal side effects in research settings