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Alexander Cox , Davide Tamburro, Claudia Fredolini, Emanuel Petricoin, Lance Liotta, and Alessandra Luchini

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Lilly is studying retatrutide in several Phase 3 clinical trials to evaluate its potential efficacy and safety in obesity and overweight with at least one weight-related medical problem, type 2 diabetes, knee osteoarthritis, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes and metabolic dysfunction-associated steatotic liver disease

Notably, psychostimulants are known to induce oxidative stress, 55, 56, 57 whereas GLP-1R signaling, which reduces AA levels, is known to reduce it