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Therefore, developing optical probes to track ChaC1/ChaC2 in vivo or in vitro is key for fully realizing the clinical potential of ChaC1/ChaC2 as tumor markers

Since renal medullary cells, whose role is to concentrate urine, are constantly exposed to extremely high levels of sodium chloride and urea, the accumulation of betaine in renal medullary cells helps balance the hypertonicity in interstitial fluid (Kempson et al., 2014)