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These effects collectively reduce lipid accumulation and tubular injury and improve survival following renal IRI (Li et al., 2023
used optogenetics to study excitatory projection neurons and inhibitory PV neurons of the mPFC and subsequently found that an increase in the cellular E/I ratio leads to severe impairments in information processing and behaviour
Abbreviations MDS: Myelodysplastic syndromes SCD: Sickle cell disease IOC: Iron overload cardiomyopathy NTBI: Non-transferrin-bound iron LPI: Labile plasma iron DMT1: Divalent metal transporter 1 ZIP14: ZRT/IRT-like protein 14 LCN-2: Lipocalin-2 TTCC: T-type calcium channels LTCC: L-type calcium channels LCI: Labile cellular iron LIP: Labile iron pool FeS clusters: Iron-sulfur clusters DFP: Deferiprone ETC: Electron transport chain IMM: Inner mitochondrial membrane OXPHOS: Oxidative phosphorylation ROS: Reactive oxygen species Mfrn: Mitoferrin MCU: Mitochondrial calcium uniporter RIRR: ROS-induced ROS release mPTP: Mitochondrial permeability transition pore m: Mitochondrial membrane potential mtDNA: Mitochondrial DNA BCL-2: B-cell lymphoma-2 SS: Szeto-Schiller PCD: Programmed cell death BMMSCs: Bone marrow mesenchymal stromal cells MAPK: Mitogen-activated protein kinase MOMP: Mitochondrial outer membrane permeabilization DAMPs: Damage-associated molecular patterns OPA1: Optic atrophy 1 Drp1: Dynamin related protein 1 Fis1: Fission 1 RET: Reverse electron transport CoQ: Coenzyme Q10 TPP+: Triphenylphosphonium PGC-1: Peroxisome proliferator-activated receptor-gamma coactivator-1alpha KD: Ketogenic diet PPAR: Peroxisome proliferators-activated receptor SIRT: Sirutin References PONKA P
Shilpa: Liposomes 101 breaks down why this delivery method matters
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