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Pickart observed that plasma from older human donors had reduced ability to support cell proliferation in liver cell culture compared to plasma from younger donors, and he set out to identify the factor responsible for the proliferation-supporting activity

The PI3K/Akt pathway activated by IGF1R is a major anti-apoptotic pathway in neurons, which drives interest in IGF1R agonism as a potential neuroprotective strategy in preclinical research

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