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The fasting treatment consisted of 2 days with moderate calorie restriction (700800 Kcal/day), 5 days of intense calorie restriction (200 Kcal/day), followed by 3 days with the stepwise reintroduction of a normal diet

doi: 10.3892/mmr.2018.8475 53 LigumskyHWolfIIsraeliSHaimsohnMFerberSKarasikAet al

Despite enormous interest in the area of antioxidants as therapeutic tools, the development of foreign compounds as therapeutic antioxidants has provided little therapeutic benefit

Subsequent research on the peptide and other melanocortin-binding proteins helped scientists better explore the melanocortin signaling system