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These compounds are formed continuously as byproducts of aerobic metabolism, through reactions with drugs and environmental toxins, or when the level of antioxidants is diminished, all creating the condition of oxidative stress

may require redosing due to shorter half-life than some benzodiazepines

At 50100 mg , tyramine exposure can lead to a life-threatening emergency with acute target-organ damage and increased risk of stroke, myocardial infarction, and pulmonary edema