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The exact cutoff and plan are set by your prescriber and the product labeling

[8] If you experience unexplained swelling in your ankles or feet while taking Ozempic, this warrants prompt medical review as it may indicate an underlying condition requiring assessment rather than being a direct medication effect

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How Much Weight Loss Do Clinical Trials Show: Retatrutide vs Tirzepatide Weight Management Research Data Phase 3 clinical trial data places retatrutides average body weight reduction at approximately 28% over 18 months, a figure that Eli Lilly and independent commentators have described as comparable to outcomes typically associated with bariatric surgery [2]