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doi: 10.2337/ds16-0026 47 PauzaAGThakkarPTasicTFelippeIBishopPGreenwoodMPet al

GLP-1 drugs improve blood sugar control by: Enhancing insulin secretion only when glucose is high lower risk of hypoglycemia Reducing post-meal glucose spikes Supporting beta-cell function Why They Cause Weight Loss

Research on sublingual drug delivery shows this route can avoid first-pass liver metabolism and utilize the rich vascular network of the oral mucosa for direct absorption into the bloodstream

However, lean mass reduction is also affected by the degree of calorie restriction, overall rapidity of weight reduction, and presence or absence of strength training exercises [62]