semaglutide & tirzepatide vs. Tirzepatide: What's the Difference and Which Is Right for You?: Envizion Medical: Wellness Center The GLP-1 Solution: 175+ Strategies,

for Wegovy, follow the specific guidance in the product labeling

Low-dose treatment is more effective than discontinuing therapy altogether

In vivo assessment of -cell incretin sensitivity using a hyperglycemic clamp with glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) infusion

Elevated hospitalisation for HF incidence remains a concern, as reported in the SAVOR-TIMI 53 trial.5557 However, in the EXAMINE and the latest CARMELINA trials, HF incidences were neutral.58,59 DPP-4 inhibitors have been reported to inhibit degradation of endogenous peptides other than GLP-1, including stromal-cell-derived factor (SDF) 1, neuropeptide Y and substance P ( Figure 2 ).60 Potentiation of these peptides results in sympathetic activation via cyclic AMP signalling and beta-receptor activation, which may contribute to HF development and cardiac fibrosis