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Tirzepatide also mimics another hormone, glucose-dependent insulinotropic polypeptide (GIP), making it a dual GLP-1/GIP receptor agonist
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208,209 The entry of sodium into neurons causes their temporary swelling, while an increase in calcium levels initiates various Ca 2+ -dependent processes
The article names a history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, and severe kidney disease with an eGFR below 15 as reasons for a detailed conversation about whether semaglutide is appropriate at all
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