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After Reconstitution: Store at 2-8C (36-46F)

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Photo (Extrinsic) Aging Extrinsic or photoaging plays a major role in damaging the skin, which is due to the exposure to the ultraviolet (UV) rays of the sun that activate the same cascade of events (seen in chronological aging) but to a much greater extent [10, 18]

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Furthermore, cytoplasmic dsDNA levels are significantly increased in FLS from RA patients, causing upregulation of genes such as IL-6 , CXCL10 , TNF- , MMP-13 , IL-1 , and IL-8 via a cGAS-dependent mechanism that also disrupts joint homeostasis [22]

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