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To determine whether the TGF pathway might be affected by emphysema pathogenesis, we used seven previously published studies that had examined the effect of TGF ligands on gene expression to develop a collection of signatures of TGF pathway activation [1923, 30, 31]

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Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study