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Thus, determining GFR based on creatinine levels requires that doctors approximate the rate of creatinine generation, which may not take all variables into account (Shlipak, Mattes 2013)

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medRxiv (2023) 2004:23288404

The irrelevance of the reduction of F for the HEDS assay kinetics could again explain the sequential patterns and non-reciprocal K m app values in contrast to the GSSCys assays