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While it offers potential benefits such as weight loss and improved glycemic control, it also carries risks like DKA and gastrointestinal side effects

Despite marketing claims and social media comparisons labeling berberine as "nature's Ozempic," there is no credible scientific evidence that berberine directly binds to or activates GLP-1 receptors

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The incidence of type 2 diabetes has also been rising throughout the world in the past decades, with this trend of increase stabilizing and even reversing in some populations only in the last 20 years (Magliano et al., 2019)