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for instance, a phase II clinical trial of the ENaC inhibitor VX-371 failed to demonstrate significant improvements in the percentage of predicted forced expiratory volume (ppFEV1), although the treatment was generally well-tolerated

Some newer liposomal and acetylated formulations improve bioavailability, but none reliably match the cellular delivery of a doctor-supervised IV protocol

It helps providers identify metabolic risks, screen for contraindications, and guide dosing decisions, particularly in patients with complex medical histories

Pharmacists, as accessible healthcare professionals, play a key role in optimising medication use, managing symptoms and supporting patients and families during this stage of care