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Owji AA, Khoshdel Z, Sanea F et al (2002b) Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus

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The progressive ramp through the cycle is intentional: it allows the body to respond to the compound gradually, lets the provider assess tolerance and response before increasing the dose, and avoids the unnecessary load of starting at maximum dosing when the tissue is still in early repair phases