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Supplement Vitamin B12 For those with permanent B12 malabsorption, such as individuals with MTHFR gene mutations, vegans/vegetarians, IBD or ileum resection, Vitamin B12 supplementation is generally recommended

notably, this research is based on the current price of these medications in the U.S., and the calculation could change significantly if the pricing of these medications were to change

According to FDA prescribing information, these include nausea (12-24%), diarrhea (7-23%), decreased appetite (10-19%), vomiting (2-11%), constipation (5-17%), and dyspepsia (5-9%), with rates varying by dose and indication