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On the basis of such evidence, several European and American clinical guidelines recommend MPFF as a first-line adjunct to conservative management of HD [15,16]

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Methylcobalamin complements methyl folate by assisting in nerve function and collaborating to lower the likelihood of issues as a form of vitamin B12

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In such cases, mitochondrial replacement therapy (MRT) has proven effective as a precautionary measure to prevent the inheritance of mtDNA mutations

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